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CDC Health Information for International Travel (“The Yellow Book”) has been a trusted resource for over 50 years. In 1967, CDC published the first Yellow Book, a small pamphlet intended to satisfy the International Sanitary Regulations requirements (1951) and later, the International Health Regulations (IHR). Adopted by the World Health Organization (WHO) in 1969 and completely revised in 2005, the IHR are designed to ensure maximum security against the international spread of diseases, with minimum interference with world travel and commerce. A copy of the current IHR and supporting information can be found on the WHO website (

In addition to reporting public health events of international concern, the United States must also inform the public about health requirements for entering or leaving other countries, such as the need to be vaccinated against yellow fever. The Yellow Book and the CDC Travelers’ Health website aim to communicate these requirements under the IHR (2005).

The Yellow Book has expanded significantly in breadth and depth over the years. It is written primarily for clinicians, including physicians, nurses, and pharmacists. Others, such as people in the travel industry, multinational corporations, missionary and volunteer organizations, and individual travelers, can also find a wealth of information here.

Authored by subject-matter experts both within and outside CDC, the guidelines presented in this book are evidence-based and supported by best practices. Internal text citations have not been included; however, a bibliography is appended to the end of each section for those interested in more detailed information. The CDC Travelers’ Health program and the CDC Foundation are pleased to partner with Oxford University Press, Inc., to publish the 2020 edition. In addition to the printed copy, a searchable, online version of the Yellow Book can be found on the CDC Travelers’ Health website (

Although this publication includes the most current information available at the time of printing, requirements and recommendations can change. Check the CDC Travelers’ Health website ( and the online Yellow Book for regularly updated information on requirements for international travel.


Questions, comments, and suggestions for CDC Travelers’ Health, including comments about this publication, may be made through the CDC-INFO contact center, toll-free at 800-CDC-INFO (800-232-4636) 8 am to 8 pm Eastern Time (Monday–Friday, closed on holidays) or by visiting to submit your question through an online form.

Pretravel or Post travel Clinical Questions

The CDC is not a medical facility. Clinicians needing assistance with preparing patients for international travel should consider a referral to a travel clinic or a clinic listed on the International Society of Travel Medicine (ISTM) website (

Clinicians with posttravel health questions regarding their patients may refer to a clinic listed on the ISTM website, the American Society of Tropical Medicine and Hygiene website (, or a medical university with specialists in infectious diseases.

State and local health departments may also be useful resources.

Because of the complexity of some travel-related diseases, Box 1-01 lists contact information for providers needing clinical assistance.

FAQs –

International Women of Color 2023